Phenotype Image Detail

Image

Caption

Progressive cerebellar Purkinje cell degeneration and abnormalities of Purkinje dendritic arbors in Cers1^fln/Cers1^fln mice. (A-D) Calbindin D-28 immunostained sagittal sections of cerebella from three-week-old (B), four-week-old (B) and four-month-old Cers1^fln/ Cers1^fln (fln/fln) (C), and four-month-old wild type (+/+) (D) mice. Sections were counterstained with hematoxylin. Cerebellar lobules are indicated by Roman numerals. (E-H) Purkinje cells immunostained with calbindin D-28 from WT (E, G) and mutant (F, H) mice at P12 (E, F) and P17 (G, H). Scale bars: 1 mm (A-D); 50 um (E-H).

Copyright

This image is from Zhao L, PLoS Genet 2011 May;7(5):e1002063, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172719

Associated Alleles

Symbol	Name
Cers1^fln	ceramide synthase 1; flincher

Associated Genotypes

Allelic Composition	Genetic Background
Cers1^fln/Cers1^fln	NOD.Cg-Cers1^fln/Sz