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Caption | Histological examination of the skin from the trunk (Fig. 5B, 5D, 5F, 5H) and feet (Fig. 5A, 5C, 5E, 5G) of male and female Gnastm1Gwa/Gnas+ mice with maternally inherited (-m/+) and paternally inherited (-p/+) Gnas allele reveal mineralized bone formation often associated with a dense eosinophilic osteoid-like matrix in the dermis and perifollicular areas. No abnormalities were observed in wild-type mice. Occasional osteoid-like material was present without bone, immediately adjacent to hair follicles, especially in female mutant mice which had milder lesions (Fig. 5F, 5H). Subcutaneous bone frequently contained central bone marrow elements making it histologically indistinguishable from mature skeletal bone (Fig. 5B, 5D). Scale bars = 50 um. | ||||
Copyright | This image is from Huso DL, PLoS One 2011;6(6):e21755, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:174525 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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