Phenotype Image Detail

Image

Caption

(D) Quantification of filopodium length (n = 18 per group) and filopodium number/100 um vessel length (n = 7 per group) at the sprouting vascular fronts, and vascular density (n = 4 per group) in P4 controls and Sema3e^tm1Ddg/Sema3e^tm1Ddg (Sema3e^-/-) retinas. Error bars represent SEM; ***p < 0.001, *p < 0.05. (E) Triple labeling for neurofilaments (green), PECAM-1 (red), and nuclei (blue) in retinal sections of P4 mutant mice. The superficial vessels (arrowheads) over the neuronal axons ectopically invade the ganglion cell layer (GCL) of the homozygous mutant mice (arrow). Scale bars: 20 um (E).

Copyright

This image is from Fukushima Y, J Clin Invest 2011 May 2;121(5):1974-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173943

Associated Alleles

Symbol	Name
Sema3e^tm1Ddg	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, David D Ginty

Associated Genotypes

Allelic Composition	Genetic Background
Sema3e^tm1Ddg/Sema3e^tm1Ddg	involves: 129P2/OlaHsd * C57BL/6