Phenotype Image Detail

Image

Caption

Unvascularized retinal areas after tamoxifen-inducible Cre-loxP genetic recombination in the oxygen-induced retinopathy (OIR) model. Whole-mount PECAM-1 IHC in P18 OIR retinas of Kdr^tm1.1Jamb/Kdr^tm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 (Vegfr2^flox/-) mice after daily i.p. injections of 40HT or vehicle from P12. The unvascularized retinal areas represented in red were measured for the morphometric analyses. Scale bar: 1 mm.

Copyright

This image is from Fukushima Y, J Clin Invest 2011 May 2;121(5):1974-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173943

Associated Alleles

Symbol	Name
Kdr^tm1.1Jamb	kinase insert domain protein receptor; targeted mutation 1.1, Jayakrishna Ambati
Kdr^tm1Jrt	kinase insert domain protein receptor; targeted mutation 1, Janet Rossant
Tg(CAG-cre/Esr1*)1Egwa	transgene insertion 1, Gyohei Egawa

Associated Genotypes

Allelic Composition	Genetic Background
Kdr^tm1Jrt/Kdr^tm1.1Jamb Tg(CAG-cre/Esr1*)1Egwa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2