Phenotype Image Detail

Image

Caption

Unvascularized retinal areas after tamoxifen-inducible Cre-loxP genetic recombination in the oxygen-induced retinopathy (OIR) model. Whole-mount PECAM-1 IHC in P18 OIR retinas of Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}/Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} Tg(CAG-cre/Esr1*)1Egwa/0 (R26-Rhoj^Tg/Tg) mice after daily i.p. injections of 40HT or vehicle from P12. The unvascularized retinal areas represented in red were measured for the morphometric analyses. Scale bar: 1 mm.

Copyright

This image is from Fukushima Y, J Clin Invest 2011 May 2;121(5):1974-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173943

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(CAG-Rhoj,-EGFP)Auem	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Akiyoshi Uemura
Tg(CAG-cre/Esr1*)1Egwa	transgene insertion 1, Gyohei Egawa

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor^tm1(CAG-Rhoj,-EGFP)Auem Tg(CAG-cre/Esr1*)1Egwa/0	involves: C57BL/6 * CBA * DBA/2