Phenotype Image Detail

Image

Caption

(E) H&E stains of representative paraffin sections of control and Kdm4a^tm1Zpl/Kdm4a^tm1Zpl Tg(Myh6-cre)1Jmk/0 hearts 3 weeks after sham and transverse aortic constriction (TAC) operation. (F) Heart weight/body weight (HW/BW) ratios of control and mutant mice 3 weeks after sham and TAC operation (n = 10-14 per group). The HW/BW ratio after TAC operation was increased 79% compared with sham operation in control mice, whereas it was only increased 42% in mutant mice. (G) Myocyte cross-sectional areas from control and mutant mice (>200 myocytes per heart in randomly selected filed) were assessed (n = 6-8 per group). Values are mean +/- SEM. *P<0.05.

Copyright

This image is from Zhang QJ, J Clin Invest 2011 Jun 1;121(6):2447-56 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173908

Associated Alleles

Symbol	Name
Kdm4a^tm1Zpl	lysine (K)-specific demethylase 4A; targeted mutation 1, Zhi-Ping Liu
Tg(Myh6-cre)1Jmk	transgene insertion 1, Jeffery D Molkentin

Associated Genotypes

Allelic Composition	Genetic Background
Kdm4a^tm1Zpl/Kdm4a^tm1Zpl Tg(Myh6-cre)1Jmk/0	involves: 129S6/SvEv * C57BL/6