Phenotype Image Detail

Image

Caption

Absence of renal cilia in Kif3a^tm1Gsn/Kif3a^tm2Gsn Tg(Cdh16-cre)91Igr/0 mutant mice. (A-C) Immunostaining of acetylated tubulin (red) and AQP2 (green) in kidneys from control mice (A) and Kif3a^tm1Gsn/Kif3a^tm2Gsn Tg(Cdh16-cre)91Igr/0 mutants (B and C) at P21. Arrowheads, primary cilia; cd, collecting duct; hl, loop of Henle; pt, proximal tubule; cy, cyst. Insets show higher-magnification images. (Bar = 10 um.) (D-F) Scanning electron micrographs of kidneys from control mice (D) and mutants (E and F) at P21. Arrowheads, primary cilia; pc, principal cell; ic, intercalated cell; tu, tubule. [Bars = 10 (A-C) and 5 um (D-F).]

Copyright

This image is from Lin F, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5286-91. Copyright 2003 National Academy of Sciences, U.S.A. J:83293

Associated Alleles

Symbol	Name
Kif3a^tm1Gsn	kinesin family member 3A; targeted mutation 1, Lawrence SB Goldstein
Kif3a^tm2Gsn	kinesin family member 3A; targeted mutation 2, Lawrence SB Goldstein
Tg(Cdh16-cre)91Igr	transgene insertion 91, Peter Igarashi

Associated Genotypes

Allelic Composition	Genetic Background
Kif3a^tm1Gsn/Kif3a^tm2Gsn Tg(Cdh16-cre)91Igr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR