Phenotype Image Detail

Image

Caption

Abnormalities of proliferation, apoptosis, and cell polarity in Kif3a^tm1Gsn/Kif3a^tm2Gsn Tg(Cdh16-cre)91Igr/0 mutant mice. (A) Hematoxylin/eosin-stained kidney from a Kif3a^tm1Gsn/Kif3a^tm2Gsn Tg(Cdh16-cre)91Igr/0 mutant at P35. cy, cyst. (B) BrdUrd incorporation (arrowheads) in kidneys from a mutant and control littermate (Inset) at P28. (C) Apoptotic cells (arrowheads) in kidneys from a mutant and control littermate (Inset) at P21. (D) Localization of EGFR (red) and ZO-1 (green) in kidneys from a mutant at P21. Arrowheads, colocalization in apical membrane; arrows, basolateral membrane; tu, tubule. (E) Expression of AQP3 in a cystic kidney at P28. Arrowheads, basolateral membrane. (F and G) Expression of AQP2 in cystic kidneys before (F) and 30 min after (G) treatment with vasopressin. Arrowheads, cytoplasmic vesicles; arrows, apical membrane. [Bars = 20 (A) and 10 um (B-G).]

Copyright

This image is from Lin F, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5286-91. Copyright 2003 National Academy of Sciences, U.S.A. J:83293

Associated Alleles

Symbol	Name
Kif3a^tm1Gsn	kinesin family member 3A; targeted mutation 1, Lawrence SB Goldstein
Kif3a^tm2Gsn	kinesin family member 3A; targeted mutation 2, Lawrence SB Goldstein
Tg(Cdh16-cre)91Igr	transgene insertion 91, Peter Igarashi

Associated Genotypes

Allelic Composition	Genetic Background
Kif3a^tm1Gsn/Kif3a^tm2Gsn Tg(Cdh16-cre)91Igr/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR