Phenotype Image Detail

Image

Caption

(A) Representative fluorescein angiography (FA), indocyanine green angiogram (ICGA), and fundus images of Tg(BEST1-HTRA1)#Ybf/0 and wild-type (WT) littermates. The mutant mice exhibited hyperfluorescent lesions on ICGA (red arrowheads) and orange-yellow lesions on the fundus photograph (red circles). (B) Higher magnification shows polypoidal, grape-cluster structure (Upper) or loop structure (lower, red arrowhead) of ICGA lesions in mutant mice. (C) FA of an 11-mo-old mutant mouse showed speckled hyperfluorescence at the same site of an ICGA lesion (red circles), resembling occult choroidal neovascularization (CNV). (D) Composite ICGA image shows the distribution of lesions in mutant mice.

Copyright

This image is from Jones A, Proc Natl Acad Sci U S A 2011 Aug 30;108(35):14578-83. Copyright 2011 National Academy of Sciences, U.S.A. J:175227

Associated Alleles

Symbol	Name
Tg(BEST1-HTRA1)#Ybf	transgene insertion, Yingbin Fu

Associated Genotypes

Allelic Composition	Genetic Background
Tg(BEST1-HTRA1)#Ybf/0	involves: C57BL/6J