Phenotype Image Detail

Image

Caption

Normal basement membranes and collagen fibers in the Bruch's membrane of Tg(BEST1-HTRA1)#Ybf/0 mice with polypoidal choroidal vasculopathy (PCV+) despite extensive elastic lamina degradation. A red bracket indicates the missing of a long stretch of elastic lamina (EL) in mutant PCV+ mice (bottom panel). EL, elastic lamina; BM, Bruch's membrane; bm Cho, basement membrane of the choroid; OCL, outer collagenous layer; ICL, inner collagenous layer; bm RPE, basement membrane of the retinal pigment epithelium (RPE). Scale bar = 1 um.

Copyright

This image is from Jones A, Proc Natl Acad Sci U S A 2011 Aug 30;108(35):14578-83. Copyright 2011 National Academy of Sciences, U.S.A. J:175227

Associated Alleles

Symbol	Name
Tg(BEST1-HTRA1)#Ybf	transgene insertion, Yingbin Fu

Associated Genotypes

Allelic Composition	Genetic Background
Tg(BEST1-HTRA1)#Ybf/0	involves: C57BL/6J