Phenotype Image Detail

Image

Caption

(A) Edema is apparent in the E14.5 Nfat5^tm1Skc/Nfat5^tm1Skc (NFAT5-/-) embryos (b) compared with a wild-type (NFAT+/+) littermate (a). The arrow indicates the outer skin layer. (B) Histological comparison of wild-type (a and c) and mutant (b and d) embryonic heart at 14.5 days. (C) Representative photomicrograph showing proliferating cell nuclear antigen (PCNA)-positive cells (arrows) in compact zone and trabecular region in E14.5 wild-type and mutant hearts. (D) Representative photomicrography showing the (a and b) Bcl-2, (c and d) Bax and (e and f) cleaved caspase-3 staining (arrows) on E14.4 wild-type and mutant hearts. Com, compact layer; E, endocardial cushion; Endo, endocardium; Ep, epicardium; LV, left ventricle; Tr, trabecular. n = 5 Scale bar = 50 um.

Copyright

This image is from Mak MC, PLoS One 2011;6(7):e19186, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:175527

Associated Alleles

Symbol	Name
Nfat5^tm1Skc	nuclear factor of activated T cells 5; targeted mutation 1, Sookja K Chung

Associated Genotypes

Allelic Composition	Genetic Background
Nfat5^tm1Skc/Nfat5^tm1Skc	involves: 129S7/SvEvBrd * C57BL/6