Phenotype Image Detail

Image

Caption

Histological analyses of testes from adult Spink2^{Gt(327A6)Cmhd}/Spink2^{Gt(327A6)Cmhd} mutant mice. A, histological sections of seminiferous tubules prepared from testes of wild-type (Spink2^+/+) and Spink2^{Gt(327A6)Cmhd}/Spink2^{Gt(327A6)Cmhd} (Spink2^gt/gt) mice stained with hematoxylin and eosin. The seminiferous tubules in mutant mice were markedly degenerated compared with those in wild-type testes. Arrows indicate abnormal vacuoles. Some tubules contained only a few spermatogenic cells around basal compartments (asterisks). Scale bar, 100 um (upper) and 50 um (lower).

Copyright

This image is from Lee B, J Biol Chem 2011 Aug 19;286(33):29108-17 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:175913

Associated Alleles

Symbol	Name
Spink2^Gt(327A6)Cmhd	serine peptidase inhibitor, Kazal type 2; gene trap 327A6, Centre for Modeling Human Disease

Associated Genotypes

Allelic Composition	Genetic Background
Spink2^Gt(327A6)Cmhd/Spink2^Gt(327A6)Cmhd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6