Phenotype Image Detail

Image

Caption

(A-D) Hematoxylin and eosin staining of transverse sections of hearts from wild-type (WT), Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 (p38alphaKO), Mapk11^tm1Jsca/Mapk11^tm1Jsca (p38betaKO), and Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^{Tg(Sox2-cre)1Amc}/0 Mapk11^tm1Jsca/Mapk11^tm1Jsca (dKO) E13.5 littermate embryos. (E-H) Higher magnification of right ventricles showing thinner compact myocardium in p38betaKO and dKO hearts (asterisk). (I-L) Higher magnification of left ventricles showing thinner myocardium in dKO hearts (asterisk). S, septum; RV, right ventricle; LV, left ventricle. (Scale bars: A-D, 500 um; E-L, 100 um.)

Copyright

This image is from del Barco Barrantes I, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12764-9. Copyright 2011 National Academy of Sciences, U.S.A. J:176023

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Mapk11^tm1Jsca	mitogen-activated protein kinase 11; targeted mutation 1, J Simon C Arthur
Mapk14^tm2Nbr	mitogen-activated protein kinase 14; targeted mutation 14, Angel R Nebreda

Associated Genotypes

Allelic Composition	Genetic Background
Mapk11^tm1Jsca/Mapk11^tm1Jsca Mapk14^tm2Nbr/Mapk14^tm2Nbr Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129P2/OlaHsd * C57BL/6 * CBA
Mapk11^tm1Jsca/Mapk11^tm1Jsca	involves: 129P2/OlaHsd