Phenotype Image Detail

Image

Caption

Eye phenotypes of the progeny from the Srebf2^{Gt(YTA054)Byg}/Srebf2⁺ and Srebf2^lop13 complementation cross. (A) Eye image from a Srebf2^lop13/Srebf2⁺ mouse indicates normal lenses at 8 weeks of age, while the lenses from the Srebf2^{Gt(YTA054)Byg}/Srebf2^lop13 mice exhibit total cataracts (B). Histological analysis from Srebf2^{Gt(YTA054)Byg}/Srebf2^lop13 mice indicates presence of swollen fiber cells (arrow) and bladder cells (arrowhead) in the lens in comparison to highly organized lens fiber cells in the Srebf2^lop13/Srebf2⁺ cortical region (C). At the lens posterior of Srebf2^lop13/Srebf2⁺ (F) bladder cells, morgagnian globules and liquefied lens material (asterisk) was identified in contrast to clear and organized lens structures observed in Srebf2^lop13/Srebf2⁺ lenses (E).

Copyright

This image is from Merath KM, Mamm Genome 2011 Aug 21;(): and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:176249

Associated Alleles

Symbol	Name
Srebf2^Gt(YTA054)Byg	sterol regulatory element binding factor 2; gene trap YTA054, BayGenomics
Srebf2^lop13	sterol regulatory element binding factor 2; lens opacity 13

Associated Genotypes

Allelic Composition	Genetic Background
Srebf2^Gt(YTA054)Byg/Srebf2^lop13	involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J