Phenotype Image Detail

Image

Caption

A, quantification of slit lamp examination of control (WT) and Selenof^tm1Vgla/Selenof^tm1Vgla (Sep15 KO) mice. Opacity was quantified using the Lens Opacities Classification System, version II. The scale was from a completely clear (grade 0) to a fully opaque (grade 5) lens. L, left; R, right. B, representative images of opacities in mutant mice using a fundus camera. Six-month-old wild-type (WT) and mutant females were used. L, left; R, right. C-H, representative cataracts in mutant mice. Each panel shows lenses from the same animal. The left panels represent in vivo slit lamp examination, and the right panels show dark field analyses of the same lens examined in vitro. C and D, representative lenses from 2-month-old mutant females. Nuclear opacity is shown with a red arrow. E, 2-month-old WT female (control) showing no nuclear opacity. F and G, 10-month-old mutant females. Nuclear opacity is shown with red arrows. H, 10-month-old WT female that developed age-related punctate opacity.

Copyright

This image is from Kasaikina MV, J Biol Chem 2011 Sep 23;286(38):33203-12 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:176744

Associated Alleles

Symbol	Name
Selenof^tm1Vgla	selenoprotein F; targeted mutation 1, Vadim N Gladyshev

Associated Genotypes

Allelic Composition	Genetic Background
Selenof^tm1Vgla/Selenof^tm1Vgla	involves: 129 * C57BL/6