Phenotype Image Detail

Image

Caption

(A) Whole eyeball dissected from a 10-month old Selenof^tm1Vgla/Selenof^tm1Vgla (Sep15 KO) female, which had anterior nuclear cataract (white arrow). Lenses of wild-type (WT) mice were clear, while opacity was evident in mutant mice. (B) Lenses dissected from a 10-month old mutant and WT (control) male mice. (C) High magnification images from boxed region in (B). Arrows in B and C point to the detected abnormalities. Absence of abnormalities (asterisk) in the control lenses.

Copyright

This image is from Kasaikina MV, J Biol Chem 2011 Sep 23;286(38):33203-12 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:176744

Associated Alleles

Symbol	Name
Selenof^tm1Vgla	selenoprotein F; targeted mutation 1, Vadim N Gladyshev

Associated Genotypes

Allelic Composition	Genetic Background
Selenof^tm1Vgla/Selenof^tm1Vgla	involves: 129 * C57BL/6