Phenotype Image Detail

Image

Caption

Comparison of cochlear morphology between wild-type mice (A, C, E & G) and Slc26a4^tm1.1Dontu/Slc26a4^tm1.1Dontu mice (B, D, F & H). Microscopic examination of the cochlear duct revealed severe endolymphatic hydrops with dilatation of scala media, degeneration of hair cells (B) and a significant atrophy of the stria vascularis (D) in Slc26a4^tm1.1Dontu/Slc26a4^tm1.1Dontu mice. Degeneration of cochlear hair cells in the mutant mice was also revealed by fluorescence confocal microscopy (H). G, H: magnification of boxes G and H from figures E and F, respectively. B, bone; IHC, inner hair cells; OC, organ of Corti; OHC, outer hair cells; RM, Reissner's membrane; SL, spiral ligament; SV, stria vascularis; T, tunnel of Corti. Bar = 150 um (A & B), 50 um (C, D, E & F), and 10 um (G & H).

Copyright

This image is from Lu YC, PLoS One 2011;6(7):e22150, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:175861

Associated Alleles

Symbol	Name
Slc26a4^tm1.1Dontu	solute carrier family 26, member 4; targeted mutation 1.1, Department of Otolaryngology National Taiwan University Hospital

Associated Genotypes

Allelic Composition	Genetic Background
Slc26a4^tm1.1Dontu/Slc26a4^tm1.1Dontu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6