Phenotype Image Detail

Image

Caption

Comparison of vestibular morphology between wild-type mice (A, saccule; C, utricle; E, semicircular canal; G, utricular macula) and Slc26a4^tm1.1Dontu/Slc26a4^tm1.1Dontu mice (B, saccule; D, utricle; F, semicircular canal; I, utricular macula). Slc26a4^tm1.1Dontu/Slc26a4^tm1.1Dontu mice revealed a decreased amount of otoconia in the saccule and utricle (B & D, arrowhead), formation of "giant otoconia" in the utricle (D & H), ectopic otoconia in the semicircular canal (F), as well as a wide spectrum of vestibular hair cell loss and degeneration (arrows) at 8 weeks of age. Scanning electron microscopy reveals the markedly enlarged otoconia at saccule and utricle in the mutant mice (H) as compared with wild-type (G). Degeneration of vestibular hair cells in the mutant mice was also revealed by fluorescence confocal microscopy (L). J, L: magnification of boxes J and L from figures I and K, respectively. EO, ectopic otoconia; GO, giant otoconia. Bar = 50 um (A-F, I & K), and 10 um (G, H, J & L).

Copyright

This image is from Lu YC, PLoS One 2011;6(7):e22150, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:175861

Associated Alleles

Symbol	Name
Slc26a4^tm1.1Dontu	solute carrier family 26, member 4; targeted mutation 1.1, Department of Otolaryngology National Taiwan University Hospital

Associated Genotypes

Allelic Composition	Genetic Background
Slc26a4^tm1.1Dontu/Slc26a4^tm1.1Dontu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6