Phenotype Image Detail

Image

Caption

Inner ear morphology, hearing thresholds, and otoconia of Zeb1^tm2.1Ajg/Zeb1^tm2.1Ajg(KI^G/KI^G), Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg(KI^G/KI^A) and Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg(KI^A/KI^A) mice. Paint-filled inner ears of Zeb1^tm2.1Ajg/Zeb1^tm2.1Ajg, Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg and Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg mice at E14.5 are shown from lateral (A-C), medial (D-F) and ventral (G-I) views. Zeb1^tm2.1Ajg/Zeb1^tm2.1Ajg morphology appeared normal. Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg ears had irregular contours of the semicircular canals (B), but researchers did not observe abnormal constrictions at the non-ampullated ends of the lateral semicircular canals (E). Homozygous inner ear structure is very abnormal (C), with discontinuous or partially ruptured semicircular canals (F) and shorter cochlear ducts (I). Average ABR thresholds for all homozygous ears (n = 10) are shown as while circles and Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg ears (n = 26) as black circles with the standard error of the mean (SEM). Scanning electron microscopy showed no difference in otoconia between homozygous (K) and Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg saccules (L) at P6. Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg utricles (N) had giant otoconia. a, anterior semicircular canal; c, cochlear duct; es, endolymphatic sac; l, lateral semicircular canal; p, posterior semicircular canal; s, saccule; u, utricle.

Copyright

This image is from Kurima K, PLoS Genet 2011 Sep;7(9):e1002307, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177274

Associated Alleles

Symbol	Name
Zeb1^tm1.1Ajg	zinc finger E-box binding homeobox 1; targeted mutation 1.1, Andrew J Griffith
Zeb1^tm2.1Ajg	zinc finger E-box binding homeobox 1; targeted mutation 2.1, Andrew J Griffith

Associated Genotypes

Allelic Composition	Genetic Background
Zeb1^tm1.1Ajg/Zeb1^tm2.1Ajg	C57BL/6-Zeb1^tm1.1Ajg/Zeb1^tm2.1Ajg
Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg	C57BL/6-Zeb1^tm1.1Ajg