Phenotype Image Detail

Image

Caption

Compound heterozygous Zeb1^tm2.1Ajg/Zeb1^Tw(KI^G/Tw) and Zeb1^tm1.1Ajg/Zeb1^Tw(KI^A/Tw) inner ear morphology. Paint-filled inner ears of Zeb1^tm2.1Ajg/Zeb1^Tw and Zeb1^tm1.1Ajg/Zeb1^Tw mice at E14.5 are shown from lateral (A and B), medial (C and D) and ventral (E and F) views. In Zeb1^tm2.1Ajg/Zeb1^Tw ears, the irregular contours of the semicircular canals, the constriction of the non-ampullated end of the lateral semicircular canal, and the short cochlear duct were all indistinguishable from similar findings in Zeb1^Tw/Zeb1⁺ ears. In Zeb1^tm1.1Ajg/Zeb1^Tw ears, the discontinuous or ruptured semicircular canals and cochlear ducts were indistinguishable from those of Zeb1^Tw/Zeb1^Tw and Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg ears. a, anterior semicircular canal; c, cochlea duct; es, endolymphatic sac; l, lateral semicircular canal; p, posterior semicircular canal; s, saccule; u, utricle.

Copyright

This image is from Kurima K, PLoS Genet 2011 Sep;7(9):e1002307, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177274

Associated Alleles

Symbol	Name
Zeb1^tm1.1Ajg	zinc finger E-box binding homeobox 1; targeted mutation 1.1, Andrew J Griffith
Zeb1^tm2.1Ajg	zinc finger E-box binding homeobox 1; targeted mutation 2.1, Andrew J Griffith
Zeb1^Tw	zinc finger E-box binding homeobox 1; twirler

Associated Genotypes

Allelic Composition	Genetic Background
Zeb1^tm1.1Ajg/Zeb1^Tw	B6.Cg-Zeb1^tm1.1Ajg/Zeb1^Tw