Phenotype Image Detail

Image

Caption

A, B) Upper panels are Alcian Blue/Alizarin Red staining of cartilage and bone skeletal preparations of E16.0 Fuz⁺/Fuz^{Gt(OSTGST001398)Lex} (Fuz+/-) embryos (A) and Fuz^{Gt(OSTGST001398)Lex}/Fuz^{Gt(OSTGST001398)Lex} (Fuz-/-) littermates (B). Ossification is reduced in the Fuz homozygous embryos. Lower panels are higher magnification of the head region. The anterior region of Meckel's cartilage (MC) is deformed with an ascending branch. E-H) E18.5 head preparations revealing delayed bone formation and defective craniofacial structures in the Fuz^{Gt(OSTGST001398)Lex}/Fuz^{Gt(OSTGST001398)Lex} embryos (arrows denote the malformed and ossified Meckel's cartilage). Frontal (fnt), parietal (par), premaxilla (pmx), maxilla (mx), sphenoid (sb) and basioccipital (bb) bones and other facial bones are missing. Background red staining was due to soft tissues, which were left intact.

Copyright

This image is from Zhang Z, PLoS One 2011;6(9):e24608, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177881

Associated Alleles

Symbol	Name
Fuz^Gt(OSTGST001398)Lex	fuzzy planar cell polarity protein; gene trap OSTGST001398, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Fuz^Gt(OSTGST001398)Lex/Fuz^Gt(OSTGST001398)Lex	involves: 129S5/SvEvBrd * C57BL/6