Phenotype Image Detail

Image

Caption

(B) Representative E9.5 and E11.5 embryos of controls, Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ (Ptpn11^+/+/HPRT-Cre⁺) and Ptpn11^tm1Ckq/Ptpn11⁺ Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ (Ptpn11^E76K/+/HPRT-Cre⁺) mice. Bars, 1 mm. (C) Whole mounts of E10.5 embryos produced from intercrosses between Ptpn11^tm1Ckq/Ptpn11⁺ and Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ mice were immunostained with anti-phospho-ERK antibody following standard procedures. Front nasal processes, limb buds, and somites of Ptpn11^tm1Ckq/Ptpn11⁺ Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ embryos are indicated by arrows. Bar, 1 mm.

Copyright

This image is from Xu D, J Exp Med 2011 Sep 26;208(10):1977-88, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:177285

Associated Alleles

Symbol	Name
Hprt1^tm1(CAG-cre)Mnn	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Jeffrey R Mann
Ptpn11^tm1Ckq	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Cheng-Kui Qu

Associated Genotypes

Allelic Composition	Genetic Background
Hprt1^tm1(CAG-cre)Mnn/Hprt1^+ Ptpn11^tm1Ckq/Ptpn11^+	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J