Phenotype Image Detail

Image

Caption

(A) Wild-type (WT) embryo at E8.5. Mutant Elp1^tm1Id/Elp1^tm1Id (B) and Elp1^tm1.1Id/Elp1^tm1.1Id (C) embryos at E9.5, photographed in the same magnification as the embryo shown in A. Note that mutant embryos at this stage closely resemble the WT E8.5 embryo in size and external morphology. (D) WT embryos at E9.5 (different magnification than embryos in A-C). Note that looping of the heart has already occurred at this stage. Elp1^tm1Id/Elp1^tm1Id (E) and Elp1^tm1.1Id/Elp1^tm1.1Id (F) embryos at E10.5. In the mutants, anterior cephalic development is severely compromised. In Ikbkap mutant embryos, the forward growth of heart ventricle (v) occurred in the absence of looping morphogenesis. Note the misaligned position of the outflow tract (oft) in mutant embryos compared to the embryo in D and the enlarged pericardial sac (arrowhead). (G) E10.5 Elp1^tm1.1Id/Elp1^tm1.1Id (left) and WT (right) littermates photographed together. (H-J) H&E-stained sagital sections of E8.5 WT (H), E9.5 Elp1^tm1Id/Elp1^tm1Id (I) and E9.5 WT (J) embryos. Note that at E9.5 cephalic and heart development of mutant embryos is similar to the WT E8.5 embryo in H.

Copyright

This image is from Dietrich P, PLoS One 2011;6(10):e27015, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178070

Associated Alleles

Symbol	Name
Elp1^tm1.1Id	elongator complex protein 1; targeted mutation 1.1, Ioannis Dragatsis
Elp1^tm1Id	elongator complex protein 1; targeted mutation 1, Ioannis Dragatsis

Associated Genotypes

Allelic Composition	Genetic Background
Elp1^tm1Id/Elp1^tm1Id	involves: 129S1/Sv * C57BL/6
Elp1^tm1.1Id/Elp1^tm1.1Id	involves: 129S1/Sv * C57BL/6 * CBA