Phenotype Image Detail

Image

Caption

Ultrastructure of nodal regions in Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt mice. Electron micrographs of longitudinal sections of sciatic nerves, at the level of nodes of Ranvier, from wild-type (WT; A, B (higher magnification of box in A), E) and Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt mice (KO; C, D (higher magnification of box in C), F). In the WT mouse, paranodal loops are symmetrical across the axon (A), and transverse bands are visible at the paranodal junctions (B, arrowheads). In the paranodal regions of the Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt mouse irregular paranodal loops are frequently observed (C, D), transverse bands between the axolemma and some glial loops are not apparent in some places (D, arrows), but clearly visible in others (D, arrowheads). At juxtaparanodes, cytoplasmic Schwann cell protrusions in the axon are observed in mutant mice (F, arrows) but not in WT mice (E, arrows). Scale bar: A, C, 0.7 um; B, D, 0.3 um; E, F, 0.9 um.

Copyright

This image is from Cifuentes-Diaz C, PLoS One 2011;6(9):e25043, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177866

Associated Alleles

Symbol	Name
Epb41l3^tm1.1Jglt	erythrocyte membrane protein band 4.1 like 3; targeted mutation 1.1, Jean-Antoine Girault

Associated Genotypes

Allelic Composition	Genetic Background
Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt	involves: FVB/N