Phenotype Image Detail

Image

Caption

Iridocorneal phenotypic features in Foxf2^W174R/Foxf2⁺ mice. (A) In wild-type mice, Schlemm's canal extends between the two white arrows. The trabecular meshwork is indicated by an asterisk. The ciliary body (CB) and ciliary body process (CBP) extend into the anterior chamber. The ciliary muscle is indicated by the black arrow. Iris Normal iridocorneal angle (A) indicated by double-headed arrow. (B-E) Phenotype in heterozygous Foxf2^W174R/Foxf2⁺ mice. All mice had shortened or absent Schlemm's canal and a hypoplastic CB or CBP. (C), Trabecular meshwork is hypoplastic and the iris is parallel to the cornea (no angle). (E), Trabecular meshwork is hypoplastic and iridocorneal adhesion (arrowhead) is present. Scale bar = 50 um.

Copyright

This image is from McKeone R, PLoS One 2011;6(10):e25489, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178103

Associated Alleles

Symbol	Name
Foxf2^W174R	forkhead box F2; Trp174Arg

Associated Genotypes

Allelic Composition	Genetic Background
Foxf2^W174R/Foxf2^+	involves: BALB/c * C3H/HeH