Phenotype Image Detail

Image

Caption

Representative images of eye phenotype of aged heterozygous Foxf2^W174R/Foxf2⁺ mutant mice. A, 6 month old Foxf2^W174R/Foxf2⁺ eye (m+/) showing normal retinal termination at the edge of the optic nerve fibre layer (black arrows). B&C, sections through two other 6 month old Foxf2^W174R/Foxf2⁺ eyes showing abnormal bulge in the nerve fibre layer. The outer nuclear layer of the retina can be seen to continue at the surface of this bulging tissue (white arrows). D&E, retinal sections in 6 month eyes. F&G, corneal sections in 6 month eyes. H-J, 12 month Foxf2^W174R/Foxf2⁺ optic nerves that do not show signs of glaucomatous change. v, vein; p, photoreceptors; onl, outer nuclear layer; inl, inner nuclear layer; ce, corneal epithelium; cs, corneal stroma. Scale bar = 50 um.

Copyright

This image is from McKeone R, PLoS One 2011;6(10):e25489, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178103

Associated Alleles

Symbol	Name
Foxf2^W174R	forkhead box F2; Trp174Arg

Associated Genotypes

Allelic Composition	Genetic Background
Foxf2^W174R/Foxf2^+	involves: BALB/c * C3H/HeH