Phenotype Image Detail

Image

Caption

C, In the tail suspension test, the Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0 mice (Smad2-CNS-KO) often crossed or clasped their hind limbs, whereas control mice usually extended and shook their hind limbs. D, representative footprint patterns. The ink footprint illustrates the broad-based gait of the hind limbs of control and mutant mice at P18. E-G, footprint patterns were quantitatively assessed for step length (E), gait width (F), and step alternation uniformity (G). Mutant mice displayed significantly higher irregularity in step alternation than controls (alternation coefficient 0.47 +/- 0.3 versus 0.15 +/- 0.02, n=3). Black and gray bars represent control and mutant, respectively (n=5).

Copyright

This image is from Wang L, J Biol Chem 2011 May 27;286(21):18766-74 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173787

Associated Alleles

Symbol	Name
Smad2^tm1.1Nomu	SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL