Phenotype Image Detail

Image

Caption

A and B, gross observation of Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0 (Smad2-CNS-KO) and control mice brains at P14. Compared with those of control littermates, the mutant mice cerebella were remarkably smaller with more exposed colliculi. C-L, H&E staining of sagittal sections through medial control and mutant brains at E16.5, E18.5, P5, P14 and P18. By E16.5, we found that there are similar cell populations in mutant and control mice. By E18.5, the four principal fissures and five cardinal lobes are evident in control mice and a reduction in foliation is observed in mutants. Arrowheads indicate the fissure forming lobules (filled arrowheads) or sublobules (blank arrowheads), which do not appear in mutant mice. Arrows indicate that the tenth lobule appears to be small in mutant mice when compared with control mice and the presence of an additional specific lobule. Scale bar, 200 um.

Copyright

This image is from Wang L, J Biol Chem 2011 May 27;286(21):18766-74 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173787

Associated Alleles

Symbol	Name
Smad2^tm1.1Nomu	SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL