Phenotype Image Detail

Image

Caption

Morphological defects to Purkinje cells in Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0 (Smad2-CNS-KO) mice. A-D, immunohistochemical staining of cerebellar Purkinje cells with anti-calbindin antibody. At P7, stunted Purkinje cell dendrites in Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0 mice were compared with those of control mice. At P14, Purkinje cell dendritic arbors appeared less elaborate with fewer branches. a-d were taken from the areas indicated by rectangles. A-D (scale bar), 200 um. a-d (scale bar), 50 um. E and F, quantitation of total dendritic length (E) and dendritic branch points (F) in control and mutant mice Purkinje cells. Three mice from each genotype were analyzed. An asterisk represents p values < 0.05. Double asterisks represents p values < 0.01. Values are expressed as the means +/-S.D.

Copyright

This image is from Wang L, J Biol Chem 2011 May 27;286(21):18766-74 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173787

Associated Alleles

Symbol	Name
Smad2^tm1.1Nomu	SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL