Phenotype Image Detail

Image

Caption

Differences in islet morphology between Gt(ROSA)26Sor^{tm1(Kcnj11*V59M)Fmas}/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)23Herr/0 (BetaV59M), wild-type (WT), Tg(Ins2-cre)23Herr/0 (RIP-Cre) and Gt(ROSA)26Sor^{tm1(Kcnj11*V59M)Fmas}/Gt(ROSA)26Sor⁺ (ROSA) mice. A. Representative sections of mouse pancreas, to illustrate the differences in islet morphology. Sections were stained for insulin using 3,3'-diaminobenzidine (DAB; thus beta-cells appear brown) and counterstained with haematoxylin. Scale bar = 100 um.

Copyright

This image is from Girard CA, J Clin Invest 2009 Jan;119(1):80-90 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:144715

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(Kcnj11*V59M)Fmas	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Frances M Ashcroft
Tg(Ins2-cre)23Herr	transgene insertion 23, Pedro Luis Herrera

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(Kcnj11*V59M)Fmas/Gt(ROSA)26Sor^+ Tg(Ins2-cre)23Herr/0	involves: 129S4/SvJae * C57BL/6