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Caption | (A) Freshly isolated keratinocytes plated at the same density on a mixture of collagen I and fibronectin. Although control cells are well spread, Itgb1tm1Ref/Itgb1tm12.1Ref Tg(KRT5-cre)5132Jlj/0 (YY/AA) mutant cells do not spread and adhere properly. Cells at the indicated time points after seeding are shown. Bar, 25 um. (B) Keratinocytes were cultured for 2 days on a mixture of collagen I and fibronectin and immunostained for Itgb1, talin, vinculin (red), and F-actin (phalloidin; green). Nuclei were stained with DAPI (blue). Itgb1tm1Ref/Itgb1tm12.1Ref Tg(KRT5-cre)5132Jlj/0 cells fail to develop focal adhesions and to organize the actin cytoskeleton. Shown are representative pictures from three independent experiments. Bar, 10 um. | ||||||
Copyright | This image is from Czuchra A, J Cell Biol 2006 Sep 11;174(6):889-99, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:177979 | ||||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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