Phenotype Image Detail

Image

Caption

A, adult mice at 6-12 months old were examined for abnormalities, and representative images are shown. A1, normal urogenital tract including kidneys, ureters, seminal vesicles, and testicles was shown in a Lzts2^tm1.1Zsu/Lzts2^tm1.1Zsu (-/-) male mouse. A2, a mutant male mouse had a normal right kidney, ureter, and seminal vesicle but had left kidney hydronephrosis, mildly dilated and shortened left ureter, and malformed left seminal vesicle. A3, a mutant female mouse showed normal left kidney and ureter but right hydronephrosis and left uterine horn pyometra. A4, a mutant male mouse showed duplicated left kidney with mildly dilated and shortened ureters and left seminal vesicle ectasia. A5, a mutant male mouse showed normal right kidney and ureter, mild left kidney hydronephrosis, and dilated shortened left ureter with left seminal vesicle ectasia. A6, a mutant female mouse showed bilateral hydronephrosis with duplicated right ureters. B, embryos at E17.5 were examined for gross urinary tract abnormalities and representative images were shown. B1 and B2, urinary tract from a wild-type (+/+) embryo. B3 and B4, urinary tract from a mutant embryo revealed double ureters, accompanied by hydroureter and hydronephrosis (blue arrow). C, newborn mice were examined by histology for urinary tract abnormalities and representative sections were shown. C1, normal urinary tract from a mutant neonate at lower magnification. C2, urinary tract from a mutant neonate at lower magnification showed right kidney hydronephrosis and hydroureters (blue arrows) and left kidney duplex renal pelvises connected to double ureters (red arrows). C3, a mutant neonate showed double renal pelvises in the right kidney (red arrows), in which the nephrogenic zones were not restricted to the cortex, indicating a duplex kidney. C4 and C5, normal kidney tissues from the mutant neonate (C1) were examined at 40 X and 200 X magnification.C6 and C7, histological examination of the mutant mouse kidney tissues (C3) with both 40 X and 200 X magnification was shown.

Copyright

This image is from Peng Y, J Biol Chem 2011 Nov 18;286(46):40331-42 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:178154

Associated Alleles

Symbol	Name
Lzts2^tm1.1Zsu	leucine zipper, putative tumor suppressor 2; targeted mutation 1.1, Zijie Sun

Associated Genotypes

Allelic Composition	Genetic Background
Lzts2^tm1.1Zsu/Lzts2^tm1.1Zsu	B6.Cg-Lzts2^tm1.1Zsu