Phenotype Image Detail

Image

Caption

A and B, focal plane by three-dimensional reconstruction of isolectin B4 (IB4, blue) staining in Angptl4^tm1Vlcg/Angptl4⁺ (angptl4^+/LacZ) and Angptl4^tm1Vlcg/Angptl4^tm1Vlcg (angptl4^LacZ/LacZ) retinas. ZO-1 (TJP1, red) (C and D) and VE-CAD (CDH5, green) (E and F) staining reveals discontinuous endothelial junctions in area 2 of homozygous mutant vasculature (the arrows point to discontinuous junctions at branch points and the arrowheads indicate tortuous-like junctions (D and F). Scale bar=15um. G and H, schematic representation of the endothelial surface of IB4 staining (blue) and endothelial junctions of VE-CAD and ZO-1 staining (light blue tracing). Endothelial junctions are poorly developed in Angptl4^tm1Vlcg/Angptl4^tm1Vlcg capillaries (H) compared with mature junctions in control retinas (G).

Copyright

This image is from Perdiguero EG, J Biol Chem 2011 Oct 21;286(42):36841-51 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:177790

Associated Alleles

Symbol	Name
Angptl4^tm1Vlcg	angiopoietin-like 4; targeted mutation 1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Angptl4^tm1Vlcg/Angptl4^tm1Vlcg	Not Specified