Phenotype Image Detail

Image

Caption

Hemisphere brain was dissected by separating hippocampus from cortex and thalamus. (A, B) Transmission electron microscope (TEM) images of the electron dense region in CT-GFP stable H4 human neuroglioma cells show the composition, filamentous organization, and cross-hatched appearance of the inclusions. (C-J) TEM images of hippocampus in Gt(ROSA)26Sor^tm1Uga/Gt(ROSA)26Sor^tm1Uga Tg(Thy1-cre)703Vaw/0 (R26CT+/+;Cre+) mice at 6 months reveal model Hirano bodies with characteristic structure and periodicity. The small size of filamentous inclusions are enclosed by myelin sheath and resemble the ultrastructural definition of Hirano bodies reported in the hippocampus of an Alzheimer's patient. Scale bars: 500 nm (A, C, E, G), 200 nm (B, D, F, H), 50 nm (I), and 20 nm (J). White square box shows a filamentous array that is magnified in the inset (B, D, F, and H).

Copyright

This image is from Ha S, BMC Neurosci 2011;12():97, an open-access article, licensee BioMed Central Ltd. J:179833

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1Uga	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Marcus Fechheimer
Tg(Thy1-cre)703Vaw	transgene insertion 703, Valerie A Wallace

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1Uga/Gt(ROSA)26Sor^tm1Uga Tg(Thy1-cre)703Vaw/0	involves: C3H * C57BL/6 * C57BL/6J