Phenotype Image Detail

Image

Caption

Microglia activation in the white matter of Ercc6^tm1Gvh/Ercc6^tm1Gvh (Csb^-/-) mice. Photomicrographs of Mac2-stained transverse brain sections of a 25 week old wild-type and Ercc6^tm1Gvh/Ercc6^tm1Gvh mouse showing a high concentration of Mac2-positive microglia cells occurs throughout the nervous system of the mutant mouse (E-H). Individual or clustered Mac2-positive microglia cells are concentrated in regions containing myelinated axons such as the corpus callosum (cc), the internal capsule (ic) bundles in the striatum, the fimbria fornix (f), the cerebella white matter, the mesencephalic (MesRF), and medullary reticular formation (RF). No or a low number of Mac2-immunoreactive cells occur in grey matter regions, such as the Neocortex NCx), the hippocampal subfields (DG (dentate gyrus), CA1 and CA3), and the medial (MVe) and lateral (LVe) vestibular nuclei. Scale bar in A: 200 um.

Copyright

This image is from Jaarsma D, PLoS Genet 2011 Dec;7(12):e1002405, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179808

Associated Alleles

Symbol	Name
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst

Associated Genotypes

Allelic Composition	Genetic Background
Ercc6^tm1Gvh/Ercc6^tm1Gvh	involves: 129P2/OlaHsd * C57BL/6J