Gene Expression Image Detail

Reference

Figure

ID

J:96463 Moraes F, et al., Mech Dev. 2005 Feb;122(2):199-212

2

MGI:5435291

Image

Caption

Wild-type (A,C,E,G,I) and Tbx1-/- (B,D,F,H,J) E9.5 embryos were analyzed by in situ hybridization. B,D,F: In the Tbx1-/- mutants, the white arrow indicates abnormal migration of of neural crest cells into the first arch. Brackets indicate the second and more caudal branchial arches. Arrowheads in E and F indicate the border between rhombomeres 2 and 1. G-J: Frontal sections through the branchial arch region. The labeled neural crest cells are adjacent to the mesodermal core (red asterisk), and not to the vessels (arrow). The arrowhead shows the neural crest stream invading the first arch (I) from r4. Sections are oriented with rostral at the top. Only the left side is shown, being lateral on the left. Abbreviations: I, first branchial arch; II, second branchial arch; r4, rhombomere 4; o, otic vesicle.

Copyright

Reprinted with permission from Elsevier from doi:10.1016/j.mod.2004.10.004 Mech Dev 122: 199-212, Moraes F; Novoa A; Jerome-Majewska LA; Papaioannou VE; Mallo M, Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development. Copyright 2005

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
A	MGI:5435402 (Crabp1)
B	MGI:5435402 (Crabp1)
C	MGI:5435403 (Sox10)
D	MGI:5435403 (Sox10)
E	MGI:5435405 (Hoxa2)
F	MGI:5435405 (Hoxa2)
G	MGI:5435402 (Crabp1)
H	MGI:5435402 (Crabp1)
I	MGI:5435405 (Hoxa2)
J	MGI:5435405 (Hoxa2)