Phenotype Image Detail

Image

Caption

Electron micrographs of the labyrinth from E12.5 Synb^tm1.2Ics/Synb^tm1.2Ics (SynB-/-) placentae. (A) Interhemal barrier of wild-type (SynB+/+) labyrinth at the maternofetal interface (maternal blood lacuna (ml) with maternal red blood cells (mrbc) and fetal blood vessel (fv) with a nucleated fetal red blood cell (frbc) with ST-I and ST-II delineated. (B) Enlarged view of the interhemal barrier, with a gap junction (arrowhead) and a desmosome (arrow) between ST-I and ST-II, an endothelial cell (ec), a mononuclear sinusoidal trophoblast giant cell (stgc), and an ST-II-specific lipid inclusion (asterisk). (C and D) Same as A and B for a non-perturbed interhemal zona of Synb^tm1.2Ics/Synb^tm1.2Ics placenta, with a gap junction (arrowhead) and a desmosome (arrow) between the two layers and a lipid inclusion (asterisk) shown. (E) Abnormal interhemal interface in Synb^tm1.2Ics/Synb^tm1.2Ics placenta, showing two unfused T-II layer cells. (Left) Apposed membranes from T-II cells are schematized. (F) Enlarged view of the area boxed in E, showing the three ordered intercellular junctions connecting two unfused T-II layer cells: tight junction (1), adherent junction (2), and desmosome (3). Section planes showing three (G) and four (H) artificially colored and apposed T-II cells connected by intercellular junctions (arrows). (Scale bars: 1 um.)

Copyright

This image is from Dupressoir A, Proc Natl Acad Sci U S A 2011 Nov 15;108(46):E1164-73. Copyright 2011 National Academy of Sciences, U.S.A. J:180242

Associated Alleles

Symbol	Name
Synb^tm1.2Ics	syncytin b; targeted mutation 1.2, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Synb^tm1.2Ics/Synb^tm1.2Ics	involves: 129/Sv * 129S2/SvPas * BALB/c * C57BL/6