Phenotype Image Detail

Image

Caption

Structure of the labyrinth from Synb^tm1.2Ics/Synb^tm1.2Ics E17.5 placentae. Thionin staining of semithin 1-um section showing numerous intracellular "comma-like" breaks (arrows) and vacuoles (arrowheads) in the Synb^tm1.2Ics/Synb^tm1.2Ics placenta (B) but scarce in wild-type placenta (A). (C-G) Electron microscopic observations of ultrathin (80 nm) sections of mutant placentae. (C) Enlarged view of a signusoidal trophoblast giant cell (stgc) showing numerous breaks inside the cytoplasm (arrows). Overview of areas with maternal lacunae (ml) separated from each other by stgc, with an arrow indicating breaks that occur within their cytoplasm (D), which will lead to stgc disruption and formation of giant maternal lacunae (gml) as observed (E). Degenerate interhemal barrier of Synb^tm1.2Ics/Synb^tm1.2Ics placenta showing lipid resorption in T-II (F, asterisk) and abundant vacuoles in ST-I (G). (Scale bars: A and B, 50 um; C-G, 2 um.)

Copyright

This image is from Dupressoir A, Proc Natl Acad Sci U S A 2011 Nov 15;108(46):E1164-73. Copyright 2011 National Academy of Sciences, U.S.A. J:180242

Associated Alleles

Symbol	Name
Synb^tm1.2Ics	syncytin b; targeted mutation 1.2, Mouse Clinical Institute

Associated Genotypes

Allelic Composition	Genetic Background
Synb^tm1.2Ics/Synb^tm1.2Ics	involves: 129/Sv * 129S2/SvPas * BALB/c * C57BL/6