Phenotype Image Detail

Image

Caption

Lens phenotypes. (A-D) Eyes were dilated and examined by slit lamp. (A) Wild-type (WT) mice (5 months old) had clear lenses (stage 0). (B) Heterozygous Cryaa^tm1Ady/Cryaa⁺ (WT/R49C^neo) mice (3 months old) had opacity in the posterior and nuclear regions of the lens (stage 2). (C) Homozygous Cryaa^tm1Ady/Cryaa^tm1Ady (R49Cneo/R49Cneo) mice (3 months old) had a nearly complete cataract (stage 3-4). (D) Cryaa^tm1Ady/Cryaa^tm1Ady mouse lenses showed a complete cataract at 5 months (stage 4). (E, F) Cataract in lens of a newborn homozygous Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mouse with deletion of the neor gene by Cre-recombinase (R49C/R49C). Slit lamp image (E) shows a severe nuclear opacity at birth (stage 3). (F) Higher magnification of the lens shown in (E) shows the nuclear opacity covering ~70% of the lens.

Copyright

This image is from Andley UP, BMC Ophthalmol 2009;9():4, an open-access article, licensee BioMed Central Ltd. J:157274

Associated Alleles

Symbol	Name
Cryaa^tm1.1Ady	crystallin, alpha A; targeted mutation 1.1, Usha P Andley
Cryaa^tm1Ady	crystallin, alpha A; targeted mutation 1, Usha P Andley

Associated Genotypes

Allelic Composition	Genetic Background
Cryaa^tm1.1Ady/Cryaa^tm1.1Ady	involves: 129 * C57BL/6
Cryaa^tm1Ady/Cryaa^tm1Ady	involves: 129
Cryaa^tm1Ady/Cryaa^+	involves: 129