Phenotype Image Detail

Image

Caption

Images are shown for lens sections from 9.5-month-old wild-type mice containing the neo insertion (WT/WTneo) and Cryaa^tm1Ady/Cryaa⁺ mouse (WT/R49Cneo). (A) Brightfield image of the equatorial region in a WT/WTneo mid-sagittal lens section. (B) Brightfield image of the equatorial region in a Cryaa^tm1Ady/Cryaa⁺ mid-sagittal lens section. (C) Posterior region of a WT/WTneo lens shows a normal posterior capsule. (D) A heterozygous Cryaa^tm1Ady/Cryaa⁺ lens with posterior cataract. Note the extensive posterior rupture, migration of cells and cell debris (arrow), and compaction of the ruptured posterior capsule (arrowhead).

Copyright

This image is from Andley UP, BMC Ophthalmol 2009;9():4, an open-access article, licensee BioMed Central Ltd. J:157274

Associated Alleles

Symbol	Name
Cryaa^tm1Ady	crystallin, alpha A; targeted mutation 1, Usha P Andley

Associated Genotypes

Allelic Composition	Genetic Background
Cryaa^tm1Ady/Cryaa^+	involves: 129