Phenotype Image Detail

Image

Caption

Immunofluorescence analysis of fiber cells in wild-type and Cryaa^tm1Ady/Cryaa^tm1Ady lenses. Immunofluorescence staining of lens sections with an antibody to membrane intrinsic protein MIP and an Alexa568-conjugated secondary antibody (red) revealed a normal fiber cell morphology in wild-type lenses (A), whereas the Cryaa^tm1Ady/Cryaa^tm1Ady (R49Cneo/R49Cneo) lenses (B) showed disorganized fiber cells and swollen cells (arrows) enclosed by membranes. Nuclei are shown by arrowheads.

Copyright

This image is from Andley UP, BMC Ophthalmol 2009;9():4, an open-access article, licensee BioMed Central Ltd. J:157274

Associated Alleles

Symbol	Name
Cryaa^tm1Ady	crystallin, alpha A; targeted mutation 1, Usha P Andley

Associated Genotypes

Allelic Composition	Genetic Background
Cryaa^tm1Ady/Cryaa^tm1Ady	involves: 129