Phenotype Image Detail

Image

Caption

Histological sections from central and peripheral retinas of 4-week-old Rpe65^rd12/Rpe65^rd12 (Rpe65^rd12/rd12;Rho^+/+) and Rpe65^rd12/Rpe65^rd12 Rho^Tvrm4/Rho⁺ (Rpe65^rd12/rd12;Rho^Tvrm5/+) animals, n=3 mice. At 4 weeks of age, retinas of Rpe65^rd12/Rpe65^rd12 mice retained a full complement of photoreceptor nuclei. In comparison, Rpe65^rd12/Rpe65^rd12 Rho^Tvrm4/Rho⁺ mutants had only 2-3 rows of cell bodies remaining in the central ONL. The peripheral retina that also showed cell loss was better preserved than the central retina.

Copyright

This image is from Budzynski E, J Biol Chem 2010 May 7;285(19):14521-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159523

Associated Alleles

Symbol	Name
Rho^Tvrm4	rhodopsin; translational research vision model 4
Rpe65^rd12	retinal pigment epithelium 65; retinal degeneration 12

Associated Genotypes

Allelic Composition	Genetic Background
Rho^Tvrm4/Rho^+ Rpe65^rd12/Rpe65^rd12	B6.Cg-Rpe65^rd12 Rho^Tvrm4