Phenotype Image Detail

Image

Caption

A, gross view of thymic size of tamoxifen- treated (TM) x3-treated wild-type (WT) and Tg(CAG-cre/Esr1*)5Amc/0 Foxn1^tm1.1Dmsu/Foxn1⁺ (uCreER^T-fx/+), oil x3-treated Tg(CAG-cre/Esr1*)5Amc/0 Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu (uCreER^T-fx/fx), and TM x3-treated Tg(CAG-cre/Esr1*)5Amc/0 Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu (uCreER^T-fx/fx), Tg(KRT5-cre/ERT2)2Ipc/0 Foxn1^tm1.1Dmsu/Foxn1⁺ (K5CreER^T-fx/+), and Tg(KRT5-cre/ERT2)2Ipc/0 Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu (K5CreER^T-fx/fx), as well as TM x5-treated Tg(KRT5-cre/ERT2)2Ipc/0 Foxn1^tm1.1Dmsu/Foxn1⁺ (K5CreER^T-fx/+), Tg(KRT5-cre/ERT2)2Ipc/0 Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu (K5CreER^T-fx/fx), Tg(KRT18-cre/ERT2)1Rgo/0 Foxn1^tm1.1Dmsu/Foxn1⁺ (K18CreER^T-fx/+), and Tg(KRT18-cre/ERT2)1Rgo/0 Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu (K18CreER^Tfx/fx) mice (from left to right).

Copyright

This image is from Cheng L, J Biol Chem 2010 Feb 19;285(8):5836-47 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159773

Associated Alleles

Symbol	Name
Foxn1^tm1.1Dmsu	forkhead box N1; targeted mutation 1.1, Dong-Ming Su
Tg(CAG-cre/Esr1*)5Amc	transgene insertion 5, Andrew P McMahon
Tg(KRT5-cre/ERT2)2Ipc	transgene insertion 2, I Pierre Chambon

Associated Genotypes

Allelic Composition	Genetic Background
Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0	involves: 129/Sv * C57BL/6 * CBA * SJL
Foxn1^tm1.1Dmsu/Foxn1^tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0	involves: 129/Sv * C57BL/6 * SJL