Phenotype Image Detail

Image

Caption

Increased susceptibility to kainate-induced tonic-clonic seizures in Grin1^tm1Mim/Grin1^tm1Mim Grik4^tm1(cre)Mim/Grik4⁺ mice. A, The graph represents the percentage of mice with the generalized tonic-clonic seizures 1 hour after drug administration. ***, P<0.001, Fisher's exact probability test. B, Cumulative curves for the onset of seizure. Saline, n = 4-6; 8 mg/kg, n = 7-8; 12 mg/kg, n = 12. C, c-Fos immunohistochemistry in the hippocampus. Scale bar, 200 um.

Copyright

This image is from Fukushima F, PLoS ONE 2009;4(1):e3993, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:144994

Associated Alleles

Symbol	Name
Grik4^tm1(cre)Mim	glutamate receptor, ionotropic, kainate 4; targeted mutation 1, Masayoshi Mishina
Grin1^tm1Mim	glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, Masayoshi Mishina

Associated Genotypes

Allelic Composition	Genetic Background
Grik4^tm1(cre)Mim/Grik4^+ Grin1^tm1Mim/Grin1^tm1Mim	involves: C57BL/6N