Phenotype Image Detail

Image

Caption

(E and F) Images of a Bouin's fixed E12.5 Ror1^tm1.2Meg/Ror1⁺ Ror2^tm1.2Meg/Ror2⁺ (Ror1^+/-;Ror2^+/-) embryo (E, littermate control of F) and Ror1^tm1.2Meg/Ror1^tm1.2Meg Ror2^tm1.2Meg/Ror2^tm1.2Meg (Ror1^-/-;Ror2^-/-) embryo with exencephaly (F). Arrows indicate truncated and asymmetric hindlimbs; arrowhead indicates truncation of the posterior body axis. f, facial malformation; ed, edema; ex, exencephaly; fl, forelimb.

Copyright

This image is from Ho HY, Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4044-51. Copyright 2012 National Academy of Sciences, U.S.A. J:182150

Associated Alleles

Symbol	Name
Ror1^tm1.2Meg	receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.2, Michael E Greenberg
Ror2^tm1.2Meg	receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.2, Michael E Greenberg

Associated Genotypes

Allelic Composition	Genetic Background
Ror1^tm1.2Meg/Ror1^tm1.2Meg Ror2^tm1.2Meg/Ror2^tm1.2Meg	involves: 129S4/SvJae * C57BL/6 * FVB/N