Phenotype Image Detail

Image

Caption

Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/0 (Ror1^f/f;Ror2^fl/fl Wnt1-Cre) embryos exhibit sympathetic axon branching defects. (D-I) TH immunostaining in E17.5 control heterozygous (Ror1^f/+;Ror2^f/+) spleen (D), kidney (E), and bladder (F) and littermate E17.5 double homozygous mutant spleen (G), kidney (H), and bladder (I). Arrows denote axonal branches that are normally seen in control target organs but are compromised in mutant target organs. (J and K) Sympathetic chain ganglia of the double homozygous embryos appear grossly intact and show normal coalescence as shown by whole-mount TH staining.

Copyright

This image is from Ho HY, Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4044-51. Copyright 2012 National Academy of Sciences, U.S.A. J:182150

Associated Alleles

Symbol	Name
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch
Ror1^tm1.1Meg	receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.1, Michael E Greenberg
Ror2^tm1.1Meg	receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.1, Michael E Greenberg

Associated Genotypes

Allelic Composition	Genetic Background
Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S4/SvJae * C57BL/6J * CBA/J