Phenotype Image Detail

Image

Caption

C) Brains of Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Xpa^c/- CamKIIa-Cre+) and Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Csb^-/- Xpa^c/- CamKIIa-Cre+) mice sacrificed at 15, 25 and 65 weeks of age; note severe atrophy of the cortex of the 65 week old Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0 (Csb^-/- Xpa^c/- CamKIIa-Cre+) mouse (white arrows).

Copyright

This image is from Jaarsma D, PLoS Genet 2011 Dec;7(12):e1002405, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179808

Associated Alleles

Symbol	Name
Ercc6^tm1Gvh	excision repair cross-complementing rodent repair deficiency, complementation group 6; targeted mutation 1, Gijsbertus van der Horst
Tg(Camk2a-cre)1Szi	transgene insertion 1, Scott Zeitlin
Xpa^tm1Gvh	xeroderma pigmentosum, complementation group A; targeted mutation 1, Gijsbertus T J van der Horst
Xpa^tm1Hvs	xeroderma pigmentosum, complementation group A; targeted mutation 1, Harry van Steeg

Associated Genotypes

Allelic Composition	Genetic Background
Ercc6^tm1Gvh/Ercc6^tm1Gvh Xpa^tm1Gvh/Xpa^tm1Hvs Tg(Camk2a-cre)1Szi/0	involves: 129P2/OlaHsd * C57BL/6J * CBA