Phenotype Image Detail

Image

Caption

Aortas from wild-type (Asef +/+) and Arhgef4^tm1Taki/Arhgef4^tm1Taki (Asef -/-) mice were embedded in Matrigel and cultured for 8 days in the presence of bFGF, EGF, VEGF, IGF-1, and 2% serum. The regions in boxes are shown magnified. Magnification X 40 (upper panels), X 100 (lower panels). The graph shows the number of endothelial cell sprouts per aortic ring at day 8. Open bars, wild-type; filled bars, Arhgef4^tm1Taki/Arhgef4^tm1Taki mice. Results are expressed as the mean +/-S.E. of three independent experiments. *, p<0.05. Scale bar, 100 um.

Copyright

This image is from Kawasaki Y, J Biol Chem 2010 Jan 8;285(2):1199-207 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159959

Associated Alleles

Symbol	Name
Arhgef4^tm1Taki	Rho guanine nucleotide exchange factor 4; targeted mutation 1, Tetsu Akiyama

Associated Genotypes

Allelic Composition	Genetic Background
Arhgef4^tm1Taki/Arhgef4^tm1Taki	involves: C57BL/6 * C57BL/6J * CBA