Phenotype Image Detail

Image

Caption

Representative transverse sections of ductus arteriosus (DAs) from wild-type (WT) (a), Tfap2b⁺/Tfap2b^tm1Rbu (Tfap2b^+/-) (b), and two Tfap2b^tm1Rbu/Tfap2b^tm1Rbu (Tfap2b^-/-) (c, d) pups at 6 hours (h) after birth. In each, the DA (arrows) was inferiorly positioned and the lumen superior to the arrow was the descending aorta. The WT and heterozygous mutant DAs were completely constricted, while both homozygous mutant DAs remained patent regardless of the level of section examined. ao, descending aorta. The lower panel showed the pathological changes in the lungs. The WT pup was sacrificed at 6 h after birth (e). The section in the middle was from a homozygous mutant pup that survived until 6 h and was sacrificed at 6 h (f). The third section was from a homozygous mutant neonate that died at 5 h after birth (g). Marked congestion of the pulmonary capillaries and disorganized alveolar structures were seen in the lungs of homozygous mutant mice. These pathological changes were more severe in the dead homozygous mutant pups.

Copyright

This image is from Zhao F, PLoS One 2011;6(7):e22908, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:175832

Associated Alleles

Symbol	Name
Tfap2b^tm1Rbu	transcription factor AP-2 beta; targeted mutation 1, Reinhard Buettner

Associated Genotypes

Allelic Composition	Genetic Background
Tfap2b^tm1Rbu/Tfap2b^tm1Rbu	involves: 129S1/Sv * 129X1/SvJ