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Caption | (A) Prior to TRAP staining, osteoclasts of all three genotypes were of relatively similar size. Cd68tm1Xfen/Cd68tm1Xfen (-/-) osteoclasts demonstrated intracellular vacuole-like structures that were not present to such an extent in CD68-expressing cells. Scale bars are 100 um. Images are representative of 3 independent experiments. (B) During the fixation process (fixative: 25 mL citrate solution [18 mM citric acid, 9 mM sodium citrate, 12 mM sodium chloride, pH 3.6], 68 mL acetone, 8 mL 37% formaldehyde), many homozygous mutant osteoclasts were reduced in size and partially detached from the culture substrate resulting in a smaller size following TRAP staining. Scale bars are 200 um. Images are representative of 3 independent experiments. | ||||
Copyright | This image is from Ashley JW, PLoS One 2011;6(10):e25838, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:178120 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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